PrEP...Forever? When Do You Stop Taking PrEP
Part 9 In A Series On PrEP By
Jake Sobo

I was sitting with a group of friends in San Francisco talking excitedly about PrEP last weekend. San Francisco’s demonstration projects have begun enrolling, and the word is on the street. Indeed, since SF was one of the cities where participants were recruited for the original iPReX study that determined that PrEP was so highly effective, the word on PrEP has been circulating in the gay bay for years now. I even noticed about a half a dozen online profiles where guys proudly declared that they were on PrEP, which I haven’t yet seen anywhere else in my travels.

The topic of conversation turned to a mutual friend, “Jon,” who recently decided to go off PrEP. “Yea, Jon just got into a relationship so he stopped taking it. They’re monogamous, I guess.” I know the friend in question. God bless him; he has a history of repeatedly getting into three month-long mini-relationships that don’t involve condoms from the get-go. Of course, no judgment here. I just prefer to skip the relationship and go straight for the bareback sex. But I couldn’t help but blurt out, “Is he crazy? They just started dating!”

HIV risk isn’t like a coat you can check at the relationship door. For starters, HIV antibody tests simply cannot detect recent infections – meaning that Jon’s new partner who’s breeding him on the regular could already be positive. Most new infections are estimated to be the result of sex with someone who didn’t know that they were positive. I’m sure Jon’s new boyfriend is a very nice boy, but let’s also not forget that “monogamous” relationships are often not really monogamous. People cheat. A study of gay male relationships recently found that 20% of gay couples who participated reported breaking their sexual agreement, and less than half of those that broke the agreement disclosed their transgression to their partner. Hell, I cheated on my ex. He cheated on me. Our version of monogamy was just chock-fucking-full of bareback sex with other people.

I get that there are guys out there in loving, committed, monogamous relationships. I don’t deny their existence. I simply question the logic of throwing your Truvada stash out the window 30 seconds after becoming someone’s boyfriend. It may make more sense for guys in Jon’s situation to keep taking PrEP for a while after getting together to figure out if this is a three-month jaunt or something more long-term.

This isn’t unlike Australia’s well-known “Talk. Test. Trust” model that advised new couples on how to go about discontinuing condoms with their primary partner back in the 1990s. Trust and open communication are critical in this model (as they are for a healthy relationship in general), as is continued HIV testing that extends beyond any potential “window period” when an HIV test might fail to detect a recent infection. We can adapt it here for PrEP. “Talk. Test. Truvada. Test. Trust.” It’s not as catchy, but the idea is the same.

Jon’s situation got me thinking. After my last disastrous attempt (and failure) with monogamy, I made a pledge to never get into another monogamous relationship. I’m just not built for it. I love sex, and I love sex with lots of people. Maybe my ideas will change someday, but from where I’m sitting I just can’t imagine being monogamous with anyone ever again.

For guys like me who have no desire to be monogamous, is there an endgame for PrEP? Outside the development of an HIV vaccine, I can’t actually imagine a foreseeable future in which stopping PrEP makes obvious sense.  That’s a daunting thought. Am I going to be popping these blue pills for the rest of my life?

Well, maybe not pills. Trials are moving through the pipeline to evaluate an injectable version of PrEP that would only require a shot once a month. From what I understand, attempts to develop a version of that drug that would only require injections once every three months are not far behind. I suppose that’s some comfort.

What do you guys think? Would you stop taking PrEP if you got into a relationship? Shoot me an email at I would love to hear from you!

Jake Sobo is a pen name used for anonymity. Jake has worked in the world of HIV prevention for nearly a decade, and is eager to share his experiences taking PrEP. Having closely followed the development of PrEP from early trials to FDA approval, he was excited to give it a shot when it was approved for use among MSM for preventing HIV.He has spent the better part of his adult life having as much sex as possible while trying to avoid contracting HIV, and started taking PrEP as a way to help him stay negative. He is well aware that the drug is not 100% effective and that he could test positive; while he hopes that does not happen, he knows that he can rely on his numerous HIV-positive friends to deal with that situation should he seroconvert. 

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  1. Jake posted on 01/17/2013 04:06 PM
    42% reduction is not what i would call "so highly effective".
    otherwise good piece.
  2. Jacko posted on 01/18/2013 01:29 AM
    More about relationships than truely about PrEP
  3. Matthew posted on 01/18/2013 08:29 AM
    My understanding is that iPReX showed a 96% reduction in HIV risk amongst those who were adherent, which is similar to the reduction in risk of condom use.
    1. Roger Klorese posted on 07/11/2014 12:31 PM
      @Matthew Actually, the study analysis really indicates 99% reduction at 100% adherence, 96% at near-100%.
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